Buy Extra Super P Force Tablets Generic drug of Sildenafil/Dapoxetine online at a reasonable price from most trusted website to cure Erectile Dysfunction. Get all information regarding this medication like the review, use, side effect, dosage (Missed/Over), Composition, Substitutes, Precautions, manufactured by Sunrise Remedies Pvt Ltd, how it works, how long does last. You can also get fast delivery in Australia, UK, USA, France, China.
Extra Super P Force 200mg Tablets (Sildenafil Citrate 100mg & Dapoxetine 100mg) is a new form of hybrid combination treatment of ED and premature ejaculation (ejaculatio praecox).
Sildenafil is a Selective inhibitor cyclic guanosine monophosphate(cGMP) specific phosphodiesterase type-5 (PDE5).
Dapoxetine is a short-acting serotonin reuptake inhibitor (SSRI) develop specifically for the treatment of premature ejaculation. Each film coated tablets contain Sildenafil Citrate 100mg and Dapoxetine 100mg.
Extra Super P Force is the treatment of male erectile dysfunction and premature ejaculation.
In Contraindication Contraindicated in patients with known hypersensitivity to any component of the tablets. Consistent with it knows the effect on the nitric oxide/cGMP pathway, Sildenafil was shown to potentiate the hypotensive effect of nitrates, and its administration to patients who are using organic nitrate, either regularly and intermittently, in any form is therefore contraindicated. Sildenafil is not specified for use in women and individuals below 18 years.
Sildenafil: The physiologic mechanism action of the erection of the panis require the circulate of nitricoxide in the corpus cavernosum during sexual stimulation. Nitricoxide then activates the enzyme guanylate cyclase, Which results in increasing level of cGMP (cyclic guanosine monophosphate), producing smooth muscle composure in the corpus cavernosum and permit inflow of blood, Sildenafil has no direct relaxant effect or isolated human corpus cavernosum,
However, enhances the effect of nitric oxide by inhibiting phosphodiesterase type-5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. When sexual stimulation purpose local release of nitric oxide, inhibition of PDE5 by sildenafil causes increased level of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses does not affect in the absence of sexual stimulation.
Dapoxetine: Dapoxetine exhibits its efficacy by perimirilary inhibiting the reuptake of the serotonin transporter. It was also shown to bind and inhibit reuptake the transporters of dopamine and norepinephrine.
The safe indicated the dose of Extra Super P Force tablet within a 24 hr period is 100mg Sildenafil Citrate / 100mg Dapoxetine. This medicine will become effective one hr after taking it and effects may be noticeable after 45mins. Effective treatment time is 4 - 6 Hrs.
Store in cool and dry places below 30 C. (Keep out of reach of children)this medicine is Available in a blister of 4 Tablets.
The recommended dose is once daily approximately one hour before sexual activity.
Take a forgot dosage as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your regular time. Don’t take 2 dosages at the same time or extra dosages.
Contact your specialist if an overdose of this drug is suspected.
As per expert reviews, there are some major and minor side effects which as follow.
There are some minor side-effects associated with the use of this pill which is as follows
Severe cardiovascular, cerebrovascular and vascular events have been reported in the temporal association with sildenafil uses; It is not possible to control whether these events are related directly to sildenafil, to the sexual act, to the patient's underlying cardiovascular disease, to a combination of these two factors or other factors.
There are some Major side-effects associated with the use of this pill which is as follows
In vitro studies: Sildenafil metabolism is principally mediated by the cytochrome P-450 (CYP) isoforms 3A4 (primary root) and 2C9 (minor root). But, inhibitors of these isoenzymes may reduce sildenafil clearance.
In vivo studies: Cimetidine (800mg), a known specific CYP inhibitor, caused a 56% increase in plasma sildenafil concentration when co-administered with sildenafil (50mg) to healthy volunteers.
Strong CYP3A4 inhibitors such as itraconazole or ketoconazole would be expected to have steel greater effects, and population data from patients in clinical trials did indicate a reduction in sildenafil clearance when it was co-administered with CYP3A4 inhibitors. It can be expected that concomitant management of CYP3A4 inducers, such rifampin, will decrease plasma level of sildenafil.
Ritonavir, highly potent P4-50 inhibitor, resulted in 300% increase in sildenafil C-max and 1000% increase in sildenafil plasma AUC.single doses of antacid (magnesium hydroxide, Aluminum hydroxide) did not affect the bioavailability of sildenafil.
Pharmacokinetic data from patients in clinical trials shown no effect on sildenafil pharmacokinetics of CYP2C9 inhibitors (such tolbutamide, warfarin), CYP2D6 inhibitors (such selective serotonin reuptake inhibitors, a tricyclic antidepressant), thiazide and related diuretics, ACE inhibitors and calcium channel brokers.
The AUC of the active metabolite, N-desmethyl generic sildenafil, increased 62% by the loop and potassium-sparing diuretics and 102% by known specific beta blockers. These effects on the metabolite are not envisaged to be of clinical consequences.
Always take this Extra Super P Force with a large glass of water.
Avoid large/ fatty meals close to when you intend to take the medication.
There are no manage clinical data on the safety /efficacy of sildenafil of the following group, if prescribed, these should be done with caution.
Suffered who have suffered a myocardial infarction, stroke, life-threatening arrhythmia within the last six month.
Patients with resting hypertension (BP<90/50) or (BP>170/110)
Patients with cardiac failure or coronary arteries disease causing unstable angina.
Patients with retinitis a minority of these patients have genetic disorders or retinal phosphodiesterase(pigmentosa).
Currently, there is no documented drug-drug interaction associated with dapoxetine. Coadministration of dapoxetine with ethanol did not produce any significant pharmacokinetic changes.
Alcohol will reduce the effectiveness of Extra Super P Force medicine and if taken in excess could lead to drowsiness, decreased self-awareness, dizziness, and altered judgment.
There are no well-controlled studies and adequate of the combination of sildenafil and dapoxetine in pregnant women. It is not indicated in women.
Extra Super P Force drug is not indicated in nursing mother.
a combination of sildenafil and dapoxetine is not indicated in children.
Yes, you would have to consult a doctor who would provide you with a medical prescription before purchasing these tablets.
These medicines can be purchased from any pharmaceutical, and safe generic pharmacy.
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