Lodonak BP Tablets (Naltrexone/Bupropion)
Medicine OverView
This medicine is a prescription combination tablet containing Naltrexone and Bupropion. It is commonly prescribed for long-term weight management in adults who are obese, or overweight adults who also have weight-related medical conditions such as high blood pressure, type 2 diabetes, or abnormal cholesterol levels. It works best when used together with a reduced-calorie diet and regular physical activity.
This medicine is a combination of Naltrexone and Bupropion in extended-release tablet form. It is mainly used for chronic weight management in adults who are obese, or overweight adults who have related health problems.
It is not a general slimming pill and should only be used under medical supervision as part of a complete weight-management plan.
This medicine is prescribed for adults who need help with long-term weight control.
Doctors usually prescribe it when:
• The patient has obesity
• The patient is overweight and also has weight-related conditions such as hypertension, type 2 diabetes, or high cholesterol
It is used along with a reduced-calorie diet and increased physical activity.
This medicine works through two active ingredients:
Naltrexone helps reduce food cravings and reward-driven eating behavior.
Bupropion acts on brain chemicals involved in appetite control and energy balance.
Together, these medicines help reduce hunger, improve control over eating, and support gradual weight loss when combined with healthy lifestyle changes.
Use this medicine exactly as prescribed by your doctor.
• Swallow the tablet whole with water
• Do not crush, chew, or split the tablet
• Do not take more than the prescribed dose
• Avoid taking it with high-fat meals
• Continue following a reduced-calorie diet and exercise plan while using this medicine
Usual adult dosage:
• Week 1: 1 tablet in the morning
• Week 2: 1 tablet in the morning and 1 tablet in the evening
• Week 3: 2 tablets in the morning and 1 tablet in the evening
• Week 4 onward: 2 tablets in the morning and 2 tablets in the evening
Missed Dose:
If you miss a dose, skip it and take the next dose at the regular time. Do not take 2 doses together.
Overdose:
Overdose may increase the risk of serious problems such as seizures, fast heartbeat, confusion, severe dizziness, or loss of consciousness. Seek immediate medical help if overdose is suspected.
Minor Side Effects:
• Nausea
• Constipation
• Headache
• Dry mouth
• Dizziness
• Trouble sleeping
• Vomiting
• Increased sweating
Major Side Effects:
• Seizures
• Suicidal thoughts or unusual mood changes
• Severe allergic reaction
• Increased blood pressure or heart rate
• Liver problems
• Severe skin reaction
• Eye pain or sudden vision changes
Take special care before using this medicine if you:
• Use opioid pain medicines or recently stopped using opioids
• Have a history of seizures
• Have uncontrolled high blood pressure
• Have an eating disorder such as anorexia or bulimia
• Have liver or kidney disease
• Have depression, bipolar disorder, or suicidal thoughts
• Are pregnant, planning pregnancy, or breastfeeding
• Are taking MAO inhibitors or recently used them
Avoid alcohol misuse while taking this medicine. Always follow your doctor’s instructions.
Available branded substitute:
• Contrave extended-release tablets (Naltrexone HCl + Bupropion HCl)
Total commonly recognized substitute available: 1
Please note that availability can vary by country and pharmacy stock.
1. Is this medicine only for weight loss?
Yes, this medicine is prescribed for long-term weight management in eligible adults under medical supervision.
2. Can this medicine be taken without diet and exercise?
No. It works best when used together with a reduced-calorie diet and regular physical activity.
3. Can this medicine be used while taking opioid painkillers?
No. It should not be used with opioids because Naltrexone blocks opioid effects and may trigger withdrawal.
4. What should I do if I miss a dose?
Skip the missed dose and continue with the next scheduled dose. Do not double the dose.
5. Does this medicine need gradual dose increase?
Yes. The dose is usually increased gradually over 4 weeks to reduce side effects and improve tolerance.
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